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Home > Pre-Test Instructions > Sestamibi Stress Test

Sestamibi Stress Test

Many radiological exams require specific patient preparation prior to the exam in order to insure that the study is performed in the safest and most accurate manner possible. If you are scheduled for one of the following studies, follow the instructions exactly as written. If you have any questions or feel that you cannot comply with the instructions, be sure to call the Department of Cardiology at (716) 278-4404.

This is a two-day test.

Before the Test – Both Days:
This test will be completed in approximately 3 hours and 15 minutes in 2 days.
Check with your physician regarding any medications that should be stopped due to some medications affecting the outcome of the test.
Nothing to eat or drink except water 6 hours prior to the test.
NO coffee or tea the day of the test.
NO alcoholic beverages 24 hours prior to the test.
Bring a list of medications along with time of LAST dose.
You will be asked to sign a consent form after a physician explains the entire procedure to you in detail.

During the Test – Day 1:
The test will be completed in approximately 1 hour and 45 minutes.
The technician will place electrode patches on the chest. These electrodes are connected by wires to an electrocardiograph machine which records heartbeats.
An Electrocardiogram (EKG) will be taken while at rest.
Blood pressure and pulse and will be monitored before, during and following the test.
An intravenous line (IV) will be placed in your arm. The IV is used to administer the Nuclear Medicine and Persantine.
The Nuclear Medicine Technician will inject a small amount of technetium-99m (Sestamibi) during the test.
Sestamibi enables a specialized camera to view how well the blood is getting to the heart muscle. (This is not a dye).

During the Test – Day 2:
The test will be completed in approximately 1 hour and 30 minutes.
Upon arrival, you will receive an injection of Sestamibi followed by an hour wait.
You are to eat a light, fatty meal during the hour wait.
The blood flow will then be viewed and recorded, same as Day 1 of the test.

The information found on this site is general in nature and some of it may not apply to your specific situation. The information is also subject to change as medical knowledge advances and new methods of treatment are developed.

We encourage you to discuss your condition and treatment with your physician. Do not hesitate to contact your physician if you have any questions.

These instructions do not take the place of directions given to you by your MD.


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